Biologics have revolutionized psoriasis treatment over the last two decades. These targeted immunomodulatory therapies act directly on the cytokine pathways that are upregulated in psoriasis and other autoimmune diseases. Two major classes make up biologics in psoriasis treatment: tumor necrosis factor (TNF) inhibitors and interleukin (IL) inhibitors. TNF Inhibitors TNF inhibitors became the first available biologic...
A little less than five percent of the world’s population are estimated to suffer from more than 7,000 different types of known rare diseases. There are even more medical conditions where those who have them are too embarrassed to talk about what’s wrong or simply don’t know exactly what ails them. Yet, these individuals are...
The Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT) is a major group providing guidance for design considerations of acute pain clinical trials. IMMPACT is made up of a team consisting of some of the most respected researchers and clinicians in the field of pain medicine. As of 2016, IMMPACT recommends these ten best practices...
Atopic dermatitis (AD), also known as atopic eczema, is a common skin disorder affecting millions of people worldwide. While many cases are mild, AD can take a significant financial and emotional toll on patients and their loved ones. What are the symptoms of atopic dermatitis? AD is characterized by skin barrier function abnormalities and skin...
Proper preparation of an Investigational New Drug (IND) application is a carefully orchestrated process that requires many disciplines to collaborate in delivering a consistent message regarding the safety of an investigative compound. Proactively identifying and avoiding common IND submission pitfalls can help ensure that your application is clear, concise, and error-free. Preparation of an Investigational...
Psoriasis is an autoimmune disease that affects 7.5 million people in the United States and roughly 100 million worldwide. While its main manifestation is in unsightly, often irritating skin lesions, many patients also experience painful psoriatic arthritis. Additionally, psoriasis often comes with a wide range of other chronic conditions, including Type 2 diabetes, cardiovascular disease and...
A systemic disease with a variety of comorbidities, psoriasis is a common condition with several clinical subtypes. In this white paper, we discuss the pathogenetic and clinical aspects of psoriasis, as well as the nuances of designing and conducting psoriasis clinical trials. Psoriasis is a chronic skin disorder and the most prevalent autoimmune disease in...
Introduction Atopic dermatitis (AD), often called eczema, is a complex disorder involving skin barrier function abnormalities and skin inflammation. It is the most common skin condition in children under the age of 11 years – about 50 percent of patients develop the disease by the age of one year and up to 85 percent by...
Acne is the most common skin condition in the U.S., affecting up to 50 million Americans annually. In this white paper, we explore the history and future of acne treatment, with a focus on emerging therapies that may help patients with moderate to severe acne gain and maintain control of their acne. Acne is a...
Short-duration acute pain management trials involve a variety of complex factors that must be taken into account for successfully evaluating the safety and efficacy of a new analgesic product. These five considerations are key. 1. Choosing the Right Model There are a number of established pain models for clinical research, each with its own type, intensity,...