Tag: analgesia

Clinical Research: Phase 1 - Phase 4

The Placebo Problem, Part 11: Trial-Independent Placebo Contributors

This is the eleventh installment of our look at the increasingly high placebo response that is plaguing clinical trials in analgesia and psychiatry. Read the rest of the posts in the series here. As we discussed last week, there are so many trial-related details that can influence the magnitude of the placebo response. But there...

Clinical Research: Phase 1 - Phase 4

The Placebo Problem, Part 10: The Devil’s in the Details

This is the tenth installment of our look at the increasingly high placebo response that is plaguing clinical trials in analgesia and psychiatry. Catch up on the other posts in the series here. Over the last two weeks we’ve discussed several specific strategies to reduce the placebo response. One effort that is becoming increasingly popular...

Study Design

10 Considerations for Osteoarthritis Study Assessments

There is a great deal of variability when it comes to osteoarthritis (OA) clinical trial designs. From the type of drug being studied to the regulatory approach of the target market to the optimal route of administration, assessment selections must be carefully tailored to meet the unique needs of each individual trial. 1. Pick the...

Clinical Research: Phase 1 - Phase 4

The Placebo Problem, Part 9: Training Achieves Smaller Placebo Responses

This is the ninth installment of our look at the increasingly high placebo response that is plaguing clinical trials in analgesia and psychiatry. View the other posts in the series here. Our last post reviewed several potential strategies to reduce the placebo effect, focusing on excluding high placebo responders and alternative trial designs. Today, we’ll...

Clinical Research: Phase 1 - Phase 4

The Placebo Problem, Part 8: Finding Another Way

This is the eighth installment of our look at the increasingly high placebo response that is plaguing clinical trials in analgesia and psychiatry. Catch up on the rest of the series here. We’re now just over halfway through our Placebo Problem series. So far, we’ve examined the details of the rising placebo response, the mechanisms...

Clinical Research: Phase 1 - Phase 4

The ABC’s of OA

Chances are you’ve either personally dealt with osteoarthritis (OA) or know someone who has. This common type of degenerative joint pain represents both a heavy disease burden and a major opportunity for drug developers. Read on to learn more about: OA’s prevalence Optimal diagnostic criteria for clinical trials Treatment options What OA research looks like...

Clinical Research: Phase 1 - Phase 4

The Placebo Problem, Part 7: Drug-Placebo Interactions

Our seventh installment of The Placebo Problem continues our look at the increasingly high placebo response that is plaguing clinical trials in analgesia and psychiatry. Check out the other posts here. The placebo response is broad. It goes far beyond the effects of merely consuming a sugar pill; it is the patient’s response to the...

Clinical Research: Phase 1 - Phase 4

Chronic Pain: Conducting Clinical Trials In Osteoarthritis

It’s the leading cause of disability due to pain and the most common form of arthritis, afflicting an estimated 237 million people worldwide. Osteoarthritis (OA) occurs as the cartilage on the end of bones wears down and most often affects the hands, knees, hips, and spine – though it can damage any joint in the...

Clinical Research: Phase 1 - Phase 4

The Placebo Problem, Part 6: Measuring the Placebo Response

This is the next installment of our look at the increasingly high placebo response that is plaguing clinical trials in analgesia and psychiatry. Check out the other posts here. Over the past few weeks, we’ve discussed the psychological, neurobiological, and genetic mechanisms responsible for the placebo response. Today, we turn to the study designs used...

Clinical Research: Phase 1 - Phase 4

The Placebo Problem, Part 5: The Placebome

This is the fifth installment of our look at placebo response issues in analgesia and psychiatry clinical trials. Read other posts in the series here. Studies examining genetic variants associated with high or low placebo responses – the “placebome” – are relatively recent, but represent an important line of research that can yield insights into...