Expertise: Oncology & Hematology 84 results
Oncology & Hematology
What is Logic-Gating and Why Does It Matter in CAR-T Therapy?
Chimeric antigen receptor T-cell (CAR-T) therapy has revolutionized the treatment landscape for certain hematological malignancies, offering hope where conventional therapies have been exhausted. By reprogramming a patient’s own T-cells to recognize and attack cancer cells, CAR-T therapy embodies the promise of personalized medicine. However, challenges such as severe immune-related toxicities, antigen escape, microenvironment suppression, and…
Oncology & Hematology
Meera Belur
Dose escalation studies are pivotal in the early phases of clinical drug development for evaluating the safety profile of a new therapeutic agent and identifying a recommended dose for further investigation. These studies lay the groundwork for understanding the pharmacokinetic and pharmacodynamic properties of novel therapies and, if designed and executed thoughtfully, can move seamlessly…
Adaptive design is a progressive approach that utilizes different statistical modeling to allow for modifications to enrollment in a clinical trial after study initiation without undermining data integrity and validity. This methodology is particularly beneficial and increasingly common in phase 1 clinical trials, which focus primarily on safety, tolerability, pharmacokinetics, and pharmacodynamics. The essence of…
Oncology & Hematology