Siegrid Delgadillo

Consulting

The Shift Toward One: Why One Pivotal Study Demands One Essential TMF 

In our recent blog examining the FDA’s move toward a one pivotal trial approval pathway, we explored what this shift means for clinical strategy, regulatory engagement, and evidentiary rigor. As development programs concentrate approval decisions into a single adequate and well-controlled study, the implications extend well...

Consulting

Strengthening TMF Oversight Through a Risk-Based Approach 

The Trial Master File (TMF) has long been a cornerstone of clinical research, serving as the primary record of study oversight, documentation integrity, and adherence to GCP standards. As modern programs grow in scale and complexity—often spanning multiple regions, partners,...