What is Logic-Gating and Why Does It Matter in CAR-T Therapy?
Chimeric antigen receptor T-cell (CAR-T) therapy has revolutionized the treatment landscape for certain hematological malignancies, offering hope where conventional therapies have been exhausted. By reprogramming a patient’s own T-cells to recognize and attack cancer cells, CAR-T therapy embodies the promise of personalized medicine. However, challenges such as severe immune-related toxicities, antigen escape, microenvironment suppression, and…