A Delayed Onset Muscle Soreness (DOMS) Model for the Evaluation of Topical Analgesics

Many orally available NSAIDs are being reformulated into topical formulations for the treatment of mild to moderate soft tissue pain.

The use of topical non-steroidal anti-inflammatory drugs (NSAIDs) is the preferred method for treating mild to moderate soft tissue injuries. Reducing the systemic exposure of NSAIDs should reduce the chances of gastrointestinal (GI) and cardiovascular (CV) side effects.

The Delayed Onset Muscle Soreness (DOMS) model has been used sparingly in the past to document efficacy and safety of topically applied NSAIDs.

The aim of this study was to see if the DOMS model could be used to demonstrate the sensitivity necessary to detect an analgesic signal with an NSAID Patch versus no treatment (control patients) in patients with mild to moderate DOMS pain.

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